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BCTC

Cat. No. 3875 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: TRPV1 antagonist
Chemical Name: 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BCTC

BCTC is an orally effective vanilloid receptor 1 (TRPV1 receptor) antagonist. Inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC50 values are 6.0 and 35 nM respectively). Displays analgesic properties in rat models of inflammatory and neuropathic pain. CNS penetrant.

Compound Libraries for BCTC

BCTC is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BCTC

M. Wt 372.89
Formula C20H25ClN4O
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 393514-24-4
PubChem ID 9929425
InChI Key ROGUAPYLUCHQGK-UHFFFAOYSA-N
Smiles ClC1=CC=CN=C1N2CCN(C(NC3=CC=C(C(C)(C)C)C=C3)=O)CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BCTC

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.29 100
ethanol 14.92 40

Preparing Stock Solutions for BCTC

The following data is based on the product molecular weight 372.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.41 mL 26.82 mL
5 mM 0.54 mL 2.68 mL 5.36 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Keywords: BCTC, BCTC supplier, vanilloid, trpv1, antagonists, transient, receptors, potential, channels, TRPV, 3875, Tocris Bioscience

2 Citations for BCTC

Citations are publications that use Tocris products. Selected citations for BCTC include:

Lian et al (2017) Elevated expression of transient receptor potential vanilloid type 1 in dorsal root ganglia of rats with endometriosis. Mol Med Rep 16 1920 PMID: 28627595

Lars et al (2014) Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. J Clin Invest 124 3793-806 PMID: 25083990

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