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Submit ReviewJNJ 303
Description: Potent and selective IKs blocker
Chemical Name: 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide
Purity: ≥98% (HPLC)
Biological Activity for JNJ 303
JNJ 303 is a potent IKs blocker (IC50 = 64 nM). Displays no effects on other cardiac channels; IC50 values are 3.3, >10, 11.1 and 12.6 μM for INa, ICa, Ito and IKr currents respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).
Licensing Information
Sold with the permission of Janssen Pharmaceutica NV
Technical Data for JNJ 303
| M. Wt | 440.98 |
| Formula | C21H29ClN2O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 878489-28-2 |
| PubChem ID | 73016713 |
| InChI Key | OSGIRCJRKSAODN-UHFFFAOYSA-N |
| Smiles | O=C(C(C)(C)OC4=CC=C(Cl)C=C4)NC2C1CC(CC2C3)CC3(NS(=O)(C)=O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JNJ 303
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.02 | 25 |
Preparing Stock Solutions for JNJ 303
The following data is based on the product molecular weight 440.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 9.07 mL | 45.35 mL | 90.71 mL |
| 1.25 mM | 1.81 mL | 9.07 mL | 18.14 mL |
| 2.5 mM | 0.91 mL | 4.54 mL | 9.07 mL |
| 12.5 mM | 0.18 mL | 0.91 mL | 1.81 mL |
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Product Datasheets for JNJ 303
References for JNJ 303
References are publications that support the biological activity of the product.
Towart et al (2009) Blockade of the IKs potassium channel: an overlooked cardiovascular liability in drug safety screening? J.Pharm.Toxicol.Meth 60 1
If you know of a relevant reference for JNJ 303, please let us know.
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Keywords: JNJ 303, JNJ 303 supplier, potent, Iks, blockers, JNJ303, potassium, K+, channels, selective, slow, delayed, rectifier, current, KCNQ1, Kv7.1, voltage-gated, voltage-dependent, Voltage-Gated, Potassium, Channels, 3899, Tocris Bioscience
2 Citations for JNJ 303
Citations are publications that use Tocris products. Selected citations for JNJ 303 include:
Björk et al (2017) Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes. Front Physiol 8 884 PMID: 29163220
Jens et al (2020) Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation. Elife 9 PMID: 33095155
Do you know of a great paper that uses JNJ 303 from Tocris? Please let us know.
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