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NAADP tetrasodium salt

Cat. No. 3905 5 Citations Submit a Review Datasheet / COA / SDS
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Description: Ca2+ mobilizing agent
Alternative Names: NAADP
Chemical Name: Nicotinic acid adenine dinucleotide phosphate tetrasodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NAADP tetrasodium salt

NAADP tetrasodium salt is a Ca2+ mobilizing agent. Initiates Ca2+ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca2+ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca2+ from acidic organelles.

Technical Data for NAADP tetrasodium salt

M. Wt 832.32
Formula C21H23N6Na4O18P3
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 90488897
InChI Key NWKIGVGTZIAOCW-MCNGMCCKSA-J
Smiles [Na+].[Na+].[Na+].[Na+].NC1=C2N=CN([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)[N+]4=CC(=CC=C4)C([O-])=O)[C@@H](O)[C@H]3OP([O-])([O-])=O)C2=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NAADP tetrasodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 41.62 50

Preparing Stock Solutions for NAADP tetrasodium salt

The following data is based on the product molecular weight 832.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.4 mL 12.01 mL 24.03 mL
2.5 mM 0.48 mL 2.4 mL 4.81 mL
5 mM 0.24 mL 1.2 mL 2.4 mL
25 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets for NAADP tetrasodium salt

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for NAADP tetrasodium salt

References are publications that support the biological activity of the product.

Calcraft et al (2009) NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 459 596 PMID: 19387438

Dammerman et al (2009) NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist. Proc.Natl.Acad.Sci. 106 10678

Galion (2006) NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores. Biochem.Soc.Transactions 34 922

If you know of a relevant reference for NAADP tetrasodium salt, please let us know.

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5 Citations for NAADP tetrasodium salt

Citations are publications that use Tocris products. Selected citations for NAADP tetrasodium salt include:

Olimpia et al (2023) Mu opioid receptor-mediated release of endolysosome iron increases levels of mitochondrial iron, reactive oxygen species, and cell death. NeuroImmune Pharm Ther 2 19-35 PMID: 37027339

Nicole et al (2020) Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function. Elife 9 PMID: 32167471

Hadi et al (2018) Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells. Nat Commun 9 5022 PMID: 30479344

Wang et al (2012) TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell 151 372 PMID: 23063126

Ruas et al (2015) Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. Am J Physiol Gastrointest Liver Physiol NULL PMID: 25872774

Do you know of a great paper that uses NAADP tetrasodium salt from Tocris? Please let us know.

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