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Description: Selective α4β1 (VLA-4) inhibitor
Purity: ≥95% (HPLC)
Biological Activity for BIO 1211
BIO 1211 is a selective, high affinity α4β1 (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of α4β1 (KD = 70 pM; IC50 = 0.004 μM). Selective for α4β1 over a range of other integrins (IC50 >100 μM for α1β1, α5β1 and α6β1).
Technical Data for BIO 1211
| M. Wt | 708.8 |
| Formula | C36H48N6O9 |
| Sequence | MPUPA-LDVP |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 187735-94-0 |
| PubChem ID | 9961766 |
| InChI Key | NVVGCQABIHSJSQ-KFZSMJGVSA-N |
| Smiles | O=C(CC2=CC=C(NC(NC3=CC=CC=C3C)=O)C=C2)N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)C)C(N1CCC[C@H]1[C@@](O)=O)=O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BIO 1211
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for BIO 1211
References for BIO 1211
References are publications that support the biological activity of the product.
Chen et al (1999) Multiple activation sites of integrin α4β1 detected through their different affinities for a small molecule ligand. J.Biol.Chem. 274 13167 PMID: 10224072
Lin et al (1999) Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses. J.Med.Chem. 42 920 PMID: 10072689
Muro et al (2009) Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem. 52 7974 PMID: 19891440
If you know of a relevant reference for BIO 1211, please let us know.
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Keywords: BIO 1211, BIO 1211 supplier, Selective, high, affinity, α4β1, a4b1, alpha4beta1, very, late, antigen, VLA-4, VLA4, inhibitors, inhibits, integrins, BIO1211, Integrins, Cell, Adhesion, Molecules, 3910, Tocris Bioscience
3 Citations for BIO 1211
Citations are publications that use Tocris products. Selected citations for BIO 1211 include:
Lujan et al (2015) Early reprogramming regulators identified by prospective isolation and mass cytometry. Nature 521 352 PMID: 25830878
Fujita et al (2014) The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action. PLoS One 9 e93738 PMID: 24695572
Hanna et al (2017) Modulation of interactions of neuroblastoma cell lines with extracellular matrix proteins affects their sensitivity to treatment with the anti-GD2 ganglioside antibody 14G2a. Int J Oncol 50 1899-1914 PMID: 28393238
Do you know of a great paper that uses BIO 1211 from Tocris? Please let us know.
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