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SJ 172550

Cat. No. 3929 Submit a Review Datasheet / COA / SDS

Discontinued Product

3929 has been discontinued.

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Description: MDMX inhibitor. Disrupts MDMX-p53 interaction
Chemical Name: 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]acetic acid methyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for SJ 172550

MDMX inhibitor. Reversibly binds MDMX (EC50 = 2.3 μM). Inhibits the MDMX-p53 interaction in cultured retinoblastoma cells; frees p53 to induce apoptosis.

Technical Data for SJ 172550

M. Wt 428.87
Formula C22H21ClN2O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 431979-47-4
PubChem ID 1317464
InChI Key RKKFQJXGAQWHBZ-LICLKQGHSA-N
Smiles O=C(N(C3=CC=CC=C3)N=C2C)/C2=C/C1=CC(OCC)=C(OCC(OC)=O)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for SJ 172550

References are publications that support the biological activity of the product.

Reed et al (2010) Identification and characterization of the first small molecule inhibitor of MDMX. J.Biol.Chem. 285 10786 PMID: 20080970

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Keywords: SJ 172550, SJ 172550 supplier, disrupts, p53, MDMX, interaction, inhibitors, inhibits, SJ172550, NHPP-spermine, 3929, Tocris Bioscience

Citations for SJ 172550

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for SJ 172550

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.