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Submit ReviewANR 94
Description: Adenosine A2A antagonist
Chemical Name: 8-Ethoxy-9-ethyl-9H-purin-6-amine
Purity: ≥99% (HPLC)
Biological Activity for ANR 94
ANR 94 is an adenosine A2A receptor (AA2AR) antagonist (Ki values are 643 and 46 nM for rat and human AA2ARs respectively). Most active AA2AR antagonist for human receptors. Displays activity in the treatment of Parkinson's disease in vivo; improves parkinsonian motor deficits and tremors. Exhibits neuroprotective and anti-inflammatory effects.
Compound Libraries for ANR 94
ANR 94 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for ANR 94
| M. Wt | 207.23 |
| Formula | C9H13N5O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 634924-89-3 |
| PubChem ID | 11805896 |
| InChI Key | QUGDTMONBLMLLD-UHFFFAOYSA-N |
| Smiles | CCN2C1=NC=NC(N)=C1N=C2OCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ANR 94
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.36 | 50 | |
| ethanol | 20.72 | 100 |
Preparing Stock Solutions for ANR 94
The following data is based on the product molecular weight 207.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.83 mL | 24.13 mL | 48.26 mL |
| 5 mM | 0.97 mL | 4.83 mL | 9.65 mL |
| 10 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 50 mM | 0.1 mL | 0.48 mL | 0.97 mL |
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Product Datasheets for ANR 94
References for ANR 94
References are publications that support the biological activity of the product.
Pinna et al (2010) A new ethyladenine antagonist of adenosine A2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug. Neuropharmacology 58 613 PMID: 19951715
Volpini et al (2010) Adenosine A2A receptor antagonists: New 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease. Chem.Med.Chem. 4 1010 PMID: 19343763
If you know of a relevant reference for ANR 94, please let us know.
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Keywords: ANR 94, ANR 94 supplier, ANR94, adenosine, A2A, receptor, antagonist, AA2AR, antagonists, antiparkinsonian, activity, Adenosine, Receptors, 3937, Tocris Bioscience
1 Citation for ANR 94
Citations are publications that use Tocris products. Selected citations for ANR 94 include:
Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Circulation 14 201 PMID: 26597723
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Literature in this Area
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Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.