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Submit ReviewColivelin
Description: STAT3 activator; also protects against β-amyloid neurotoxicity
Purity: ≥95% (HPLC)
Biological Activity for Colivelin
Colivelin is a neuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant.
Technical Data for Colivelin
| M. Wt | 2645.13 |
| Formula | C119H206N32O35 |
| Sequence | SALLRSIPAPAGASRLLLLTGEIDLP |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 867021-83-8 |
| PubChem ID | 90477169 |
| InChI Key | PTTAQOYOJJTWFD-IBAOLXMASA-N |
| Smiles | [H]N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Colivelin
| Solubility | Soluble to 1 mg/ml in 20% ethanol / water |
Product Datasheets for Colivelin
References for Colivelin
References are publications that support the biological activity of the product.
Chiba et al (2005) Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro a J.Neurosci. 25 10252 PMID: 16267233
Sari et al (2009) A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations. Neuroscience 164 1653 PMID: 19782727
Yamada et al (2008) Nasal colivelin treatment ameliorates memory impairment related to Alzheimer's disease. Neuropsychopharmacology 33 2020 PMID: 17928813
If you know of a relevant reference for Colivelin, please let us know.
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Keywords: Colivelin, Colivelin supplier, neuroprotectant, neuroprotective, beta-amyloid, b-amyloid, β-amyloid, alzheimers, disease, STAT3, amyloidbeta, amyloidb, amyloidβ, Amyloid, Beta, Peptides, STAT, 3945, Tocris Bioscience
3 Citations for Colivelin
Citations are publications that use Tocris products. Selected citations for Colivelin include:
Vergani et al (2013) Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7. J Cell Biol 127 463 PMID: 23250993
Li et al (2017) The ameliorative effect of fluoxetine on neuroinflammation induced by sleep deprivation. J Neurochem PMID: 29222907
Xiaodong et al (2019) TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti-PD-1 Therapy in Melanoma. Cancer Immunol Res 7 1672-1686 PMID: 31451482
Do you know of a great paper that uses Colivelin from Tocris? Please let us know.
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Pathways for Colivelin
