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Submit ReviewAR-R 17779 hydrochloride
Discontinued Product
3964 has been discontinued.
Description: Selective α7 nAChR agonist
Chemical Name: (3S)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidine]-2'-one hydrochloride
Biological Activity for AR-R 17779 hydrochloride
Selective agonist of α7 nAChRs (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors respectively). CNS penetrant after systemic administration.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data for AR-R 17779 hydrochloride
| M. Wt | 218.68 |
| Formula | C9H14N2O2.HCl |
| Storage | Desiccate at RT |
| CAS Number | 178419-42-6 |
| PubChem ID | 9859263 |
| InChI Key | XGLBLUBBDSJBIU-FVGYRXGTSA-N |
| Smiles | O=C(NC3)O[C@@]13CN2CCC1CC2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AR-R 17779 hydrochloride
References for AR-R 17779 hydrochloride
References are publications that support the biological activity of the product.
Grottick et al (2000) Evidence that nicotinic α7 receptors are not involved in the hyperlocomotor and rewarding effects of nicotine. J.Pharmacol.Exp.Ther. 294 1112 PMID: 10945867
Mullen et al (2000) (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the α7 nicotinic acetylcholine receptor. J.Med.Chem. 43 4045 PMID: 11063601
Huang et al (2010) Activation of presynaptic α7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study. Br.J.Pharmacol. 159 554 PMID: 20105181
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2 Citations for AR-R 17779 hydrochloride
Citations are publications that use Tocris products. Selected citations for AR-R 17779 hydrochloride include:
Cao et al (2019) α7 Nicotinic Acetylcholine Receptor Signaling Modulates Ovine Fetal Brain Astrocytes Transcriptome in Response to Endotoxin. Front Immunol 10 1063 PMID: 31143190
Cortes et al (2017) α7 nicotinic acetylcholine receptor signaling modulates the inflammatory phenotype of fetal brain microglia: first evidence of interference by iron homeostasis. Sci Rep 7 10645 PMID: 28878260
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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