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Submit ReviewTazarotene
Description: Receptor-selective retinoid; binds RAR-β and -γ
Chemical Name: 6-[2-(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Biological Activity for Tazarotene
Receptor-selective acetylenic retinoid; binds at retinoid acid receptors (RAR) -β and -γ. Topically used for the treatment of skin disorders, particularly psoriasis and acne. Implicated in the treatment of basal cell carcinomas; induces upregulation of Bax in vivo. Exhibits antiproliferative and proapoptotic activity. Upregulates TIGs (Tazarotene-induced genes), including the cell adhesion molecule TIG1 and the tumor-suppressor TIG3.
Technical Data for Tazarotene
| M. Wt | 351.46 |
| Formula | C21H21NO2S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 118292-40-3 |
| PubChem ID | 5381 |
| InChI Key | OGQICQVSFDPSEI-UHFFFAOYSA-N |
| Smiles | CC1(C)C2=C(C=CC(C#CC3=NC=C(C(OCC)=O)C=C3)=C2)SCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Tazarotene
References for Tazarotene
References are publications that support the biological activity of the product.
Higuchi et al (2003) Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lungcarcinoma cells and its association with suppression of the transformed phenotype. Oncogene 22 4627 PMID: 12879006
Orlandi et al (2004) Evidence of increased apoptosis and reduced proliferation in basal cell carcinomas treated with tazar. J.Invest.Dermatol. 122 1037 PMID: 15102095
Son et al (2009) Expression and mutation analysis of TIG1 (Tazarotene-induced gene 1) in human gastric cancer. Oncol.Res. 17 571 PMID: 19806788
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Keywords: Tazarotene, Tazarotene supplier, receptor-selective, retinoid, RARbeta, RARgamma, retinoic, acid, receptor, treats, skin, conditions, Retinoic, Acid, Receptors, 3997, Tocris Bioscience
Citations for Tazarotene
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.