Home / Pharmacology / Nuclear Receptors / Estrogen and Related Receptors / Estrogen and Related Receptor Modulators / Cyclofenil

Cyclofenil

Cat. No. 3999 Submit a Review Datasheet / COA / SDS

Discontinued Product

3999 has been discontinued.

View all Estrogen and Related Receptors products.
Description: Selective estrogen receptor modulator (SERM)
Chemical Name: 4,4'-(Cyclohexylidenemethylene)bisphenol 1,1'-diacetate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for Cyclofenil

Non-steroidal selective estrogen receptor modulator (SERM). Displays higher affinity for estrogen receptor β (ERβ) than for ERα.

Technical Data for Cyclofenil

M. Wt 364.43
Formula C23H24O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 2624-43-3
PubChem ID 2898
InChI Key GVOUFPWUYJWQSK-UHFFFAOYSA-N
Smiles CC(OC(C=C3)=CC=C3/C(C2=CC=C(OC(C)=O)C=C2)=C1/CCCCC1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Cyclofenil

References are publications that support the biological activity of the product.

Kieser et al (2010) Characterization of the pharmacore properties of novel selective estrogen receptor downregulators (SERDs). J.Med.Chem. 53 3320 PMID: 20334372

Seo et al (2006) Fluorine-substituted cyclofenil derivatives as estrogen receptor ligands: synthesis and structure-affinity relationship study of potential PET agents for imaging estrogen receptors in breast cancer. J.Med.Chem. 49 2496 PMID: 16610793

View Related Products by Target

View Related Products by Product Action

View all Estrogen and Related Receptor Modulators

Keywords: Cyclofenil, Cyclofenil supplier, Non-steroidal, selective, estrogen, receptors, modulators, SERM, ERα, ERβ, Estrogen, and, Related, Receptors, 3999, Tocris Bioscience

Citations for Cyclofenil

Citations are publications that use Tocris products.

Currently there are no citations for Cyclofenil.

Reviews for Cyclofenil

There are currently no reviews for this product. Be the first to review Cyclofenil and earn rewards!

Have you used Cyclofenil?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for Cyclofenil

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.