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Submit ReviewAlda 1
Description: ALDH2 activator; cardioprotective
Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
Purity: ≥99% (HPLC)
Biological Activity for Alda 1
Alda 1 is an activator of aldehyde dehydrogenase 2 (ALDH2). Increases activity of wild-type ALDH2*1 and variant ALDH2*2 (by ~2-fold and 11-fold respectively). Capable of partly restoring mutant ALDH2*2 activity; protective against cardiac ischemia.
Compound Libraries for Alda 1
Alda 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Alda 1
| M. Wt | 324.16 |
| Formula | C15H11Cl2NO3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 349438-38-6 |
| PubChem ID | 831629 |
| InChI Key | NMKJFZCBCIUYHI-UHFFFAOYSA-N |
| Smiles | O=C(C3=C(Cl)C=CC=C3Cl)NCC1=CC(OCO2)=C2C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Alda 1
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.42 | 100 | |
| ethanol | 3.24 | 10 |
Preparing Stock Solutions for Alda 1
The following data is based on the product molecular weight 324.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.08 mL | 15.42 mL | 30.85 mL |
| 5 mM | 0.62 mL | 3.08 mL | 6.17 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.08 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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Product Datasheets for Alda 1
References for Alda 1
References are publications that support the biological activity of the product.
Chen et al (2008) An activator of mutant and wildtype aldehyde dehydrogenase reduces ischemic damage to the heart. Science 321 1493 PMID: 18787169
Beretta et al (2010) Characterization of the East Asian variant of aldehyde dehydrogenase-2. Bioactivation of nitrogly. and effects of alda-1. J.Biol.Chem. 285 943 PMID: 19906643
If you know of a relevant reference for Alda 1, please let us know.
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Keywords: Alda 1, Alda 1 supplier, aldehyde, dehydrogenases, activators, aldh2, aldh2*1, aldh2*2, aldh22, aldh21, cardiac, ischemia, Alda1, Aldehyde, Dehydrogenase, 4005, Tocris Bioscience
2 Citations for Alda 1
Citations are publications that use Tocris products. Selected citations for Alda 1 include:
Tao et al (2020) Protection of retinal function and morphology in MNU-induced retinitis pigmentosa rats by ALDH2: an in-vivo study. BMC Ophthalmol 20 55 PMID: 32070320
Ling et al (2021) Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice. Alcohol Clin Exp Res 45 1950-1964 PMID: 34486131
Do you know of a great paper that uses Alda 1 from Tocris? Please let us know.
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