Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMycophenolic acid
Description: Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
Chemical Name: 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid
Purity: ≥98% (HPLC)
Biological Activity for Mycophenolic acid
Mycophenolic acid is an immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo. Potently inhibits inosine monophosphate dehydrogenase (IMPDH), thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation.
Compound Libraries for Mycophenolic acid
Mycophenolic acid is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Mycophenolic acid
| M. Wt | 320.34 |
| Formula | C17H20O6 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 24280-93-1 |
| PubChem ID | 446541 |
| InChI Key | HPNSFSBZBAHARI-RUDMXATFSA-N |
| Smiles | COC1=C(C)C2=C(C(=O)OC2)C(O)=C1C\C=C(/C)CCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Mycophenolic acid
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.03 | 100 |
Preparing Stock Solutions for Mycophenolic acid
The following data is based on the product molecular weight 320.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.12 mL | 15.61 mL | 31.22 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Mycophenolic acid
References for Mycophenolic acid
References are publications that support the biological activity of the product.
Allison et al (1993) Mechanisms of action of mycophenolic acid. Ann.N.Y.Acad.Sci. 696 63 PMID: 7906496
Chapman et al (1997) Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat. Br.J.Pharmacol. 122 1537 PMID: 9422796
Eugui et al (1991) Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depeletion. Scand.J.Immunol. 33 161 PMID: 1826793
Goldberg et al (1998) Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 286 1007 PMID: 9694962
Senda et al (1995) Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells. Transplantation 60 1143 PMID: 7482723
Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499 PMID: 9087409
If you know of a relevant reference for Mycophenolic acid, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Mycophenolic acid, Mycophenolic acid supplier, Inosine, monophosphatase, dehydrogenases, inhibitors, inhibits, immunosuppressant, IMPDH, Other, Dehydrogenases, Immunosuppressants, Non-selective, Antivirals, 1505, Tocris Bioscience
1 Citation for Mycophenolic acid
Citations are publications that use Tocris products. Selected citations for Mycophenolic acid include:
Gomez et al (2015) Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate. PLoS One 10 e0133862 PMID: 26288179
Do you know of a great paper that uses Mycophenolic acid from Tocris? Please let us know.
Reviews for Mycophenolic acid
Average Rating: 5 (Based on 1 Review.)
Have you used Mycophenolic acid?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Used as an IMPDH inhibitor.
By
Timothy Ryan on 09/30/2024
Assay Type: Ex Vivo
Species: Rat
Cell Line/Tissue: Primary hippocampal neurons
The drug was incubated at 2 μM for 2 h to deplete intracellular GTP.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Metabolism Research Product Guide
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Glycolysis
- Tricarboxylic Acid Cycle
- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.