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Submit ReviewLPYFD-NH2
Discontinued Product
4084 has been discontinued.
Description: Binds Aβ; protects from aggregation induced toxicity
Biological Activity for LPYFD-NH2
LPYFD-NH2 is a neuroprotective peptide that binds to amyloid beta (Aβ). Protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo. Potential therapeutic in the treatment of Alzheimer's Disease.
Technical Data for LPYFD-NH2
| M. Wt | 652.75 |
| Formula | C33H44N6O8 |
| Sequence |
LPYFD-NH2 (Modifications: Asp-5 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 700361-48-4 |
| PubChem ID | 90488910 |
| InChI Key | IZXBZWOUOODINS-IRGGMKSGSA-N |
| Smiles | [H]N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LPYFD-NH2
References for LPYFD-NH2
References are publications that support the biological activity of the product.
Szegedi et al (2005) Pentapeptides derived from Aβ1-42 protect neurons from the modulatory effects of Aβ fibrils- an in vitro and in vivo electrophysiological study. Neurobiology of Disease 18 499 PMID: 15755677
Juhasz et al (2009) An intraperitoneally administered pentapeptide protects against Aβ (1-42) induced neuronal excitation in vivo. J.Alzheimer's Dis. 16 189
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Keywords: LPYFD-NH2, LPYFD-NH2 supplier, LPYFDNH2, neuroprotective, amyloid, sequence-derived, peptides, binds, beta, Ab, Aβ, Alzheimers, amyloidbeta, amyloidb, amyloidβ, Amyloid, Beta, Peptides, 4084, Tocris Bioscience
Citations for LPYFD-NH2
Citations are publications that use Tocris products.
Currently there are no citations for LPYFD-NH2.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.