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Submit ReviewNalmefene hydrochloride
Description: Opioid receptor antagonist
Chemical Name: (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Nalmefene hydrochloride
Nalmefene hydrochloride is an opioid receptor antagonist; displays a longer half life than Naloxone. Exhibits neuroprotective effects after traumatic brain injury in the rat.
Compound Libraries for Nalmefene hydrochloride
Nalmefene hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Nalmefene hydrochloride
| M. Wt | 375.89 |
| Formula | C21H25NO3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 58895-64-0 |
| PubChem ID | 5388881 |
| InChI Key | GYWMRGWFQPSQLK-OPHZJPRHSA-N |
| Smiles | C=C3[C@H]5[C@]24C1=C(O5)C(O)=CC=C1C[C@@H](N(CC6CC6)CC4)[C@@](O)2CC3.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Nalmefene hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 37.59 | 100 | |
| DMSO | 37.59 | 100 |
Preparing Stock Solutions for Nalmefene hydrochloride
The following data is based on the product molecular weight 375.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.66 mL | 13.3 mL | 26.6 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.32 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.66 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
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Product Datasheets for Nalmefene hydrochloride
References for Nalmefene hydrochloride
References are publications that support the biological activity of the product.
Vink et al (1990) Opiate antagonist nalmefene improves intracellular free Mg2+, bioenergetic state, and neurologic outcome following traumatic brain injury in rats. J.Neurosci. 10 3524 PMID: 2230942
If you know of a relevant reference for Nalmefene hydrochloride, please let us know.
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Keywords: Nalmefene hydrochloride, Nalmefene hydrochloride supplier, opioid, receptor, antagonist, antagonists, Miscellaneous/Non-selective, Opioids, 4085, Tocris Bioscience
Citations for Nalmefene hydrochloride
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