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Submit Review6-Mercaptopurine
Description: Purine analog; inhibits DNA and RNA synthesis
Chemical Name: Purine-6(1H)-thione
Purity: ≥99% (HPLC)
Biological Activity for 6-Mercaptopurine
6-Mercaptopurine is an inhibitor of de novo purine synthesis through interference with DNA and RNA synthesis. Immunosuppressive and antileukemic drug; reduces the anticoagulation elicited by warfarin. Active metabolite of azathioprine (Cat. No. 4099). Also inhibits SARS-CoV papain-like protease (PLpro; IC50 = 21.6 μM for PLpro deubiquitination activity).
Technical Data for 6-Mercaptopurine
| M. Wt | 152.18 |
| Formula | C5H4N4S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 50-44-2 |
| PubChem ID | 3000241 |
| InChI Key | GLYGRBPLZURLDD-UHFFFAOYSA-N |
| Smiles | S=C1C2C(N=CN2)N=CN1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 6-Mercaptopurine
References for 6-Mercaptopurine
References are publications that support the biological activity of the product.
Sahasranaman et al (2008) Clinical pharmacology and pharmacogenetics of thiopurines. Eur.J.Clin.Pharmacol. 64 753 PMID: 18506437
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1 Citation for 6-Mercaptopurine
Citations are publications that use Tocris products. Selected citations for 6-Mercaptopurine include:
Ari et al (2021) Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia. iScience 24 102651 PMID: 34151238
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