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Submit ReviewHexamethonium bromide
Discontinued Product
4111 has been discontinued.
View all Nicotinic Receptors (Non-selective) products.
Description: Non-competitive nAChR antagonist
Chemical Name: N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide
Biological Activity for Hexamethonium bromide
Hexamethonium bromide is a nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.
Technical Data for Hexamethonium bromide
| M. Wt | 362.19 |
| Formula | C12H30Br2N2 |
| Storage | Desiccate at RT |
| CAS Number | 55-97-0 |
| PubChem ID | 5938 |
| InChI Key | FAPSXSAPXXJTOU-UHFFFAOYSA-L |
| Smiles | C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Hexamethonium bromide
References for Hexamethonium bromide
References are publications that support the biological activity of the product.
Karavaev et al (2008) The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro. Neurosci.Behav.Physiol. 38 297 PMID: 18264777
Dasgupta et al (2010) Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proc.Natl.Acad.Sci. 103 6332
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Keywords: Hexamethonium bromide, Hexamethonium bromide supplier, Hexamethonium, Br, nicotinic, receptor, blocker, ganglion, nAChR, antagonist, Nicotinic, Receptors, (Non-selective), 4111, Tocris Bioscience
5 Citations for Hexamethonium bromide
Citations are publications that use Tocris products. Selected citations for Hexamethonium bromide include:
Xin-Ming et al (2019) Identifying roles for peptidergic signaling in mice. Proc Natl Acad Sci U S A 116 20169-20179 PMID: 31455734
Tomomi et al (2022) Patch clamp recording from bipolar cells in the wholemount mouse retina. STAR Protoc 3 101482 PMID: 35769922
Robert G et al (2021) Cholinergic feedback to bipolar cells contributes to motion detection in the mouse retina. Cell Rep 37 110106 PMID: 34910920
Gertjan et al (2021) Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels. PLoS Biol 19 e3001070 PMID: 33481771
Bernhard et al (2021) GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals. Elife 10 PMID: 33913808
Reviews for Hexamethonium bromide
Average Rating: 5 (Based on 1 Review.)
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Nicotinic blocker for decreasing stimulated dopamine release.
By
Anonymous on 05/15/2018
Assay Type: Ex Vivo
Species: Mouse
This is a fantastic drug for examining nicotinic receptor effects. It is easy to work with for slice recordings and washes out nicely. We typically use 50-200uM concentrations.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.