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Submit ReviewBepridil hydrochloride
Description: Non-selective Ca2+ channel blocker; also NCX inhibitor
Chemical Name: N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Bepridil hydrochloride
Bepridil hydrochloride is a calcium channel blocker. Also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels; opens mitochondrial KATP channels. Antiarrhythmic and antihypertensive; acts as a calcium sensitizer.
Compound Libraries for Bepridil hydrochloride
Bepridil hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Bepridil hydrochloride
| M. Wt | 403 |
| Formula | C24H34N2O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 68099-86-5 |
| PubChem ID | 50088 |
| InChI Key | JXBBWYGMTNAYNM-UHFFFAOYSA-N |
| Smiles | CC(C)COCC(N3CCCC3)CN(C2=CC=CC=C2)CC1=CC=CC=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Bepridil hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.3 | 100 |
Preparing Stock Solutions for Bepridil hydrochloride
The following data is based on the product molecular weight 403. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.48 mL | 12.41 mL | 24.81 mL |
| 5 mM | 0.5 mL | 2.48 mL | 4.96 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.48 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets for Bepridil hydrochloride
References for Bepridil hydrochloride
References are publications that support the biological activity of the product.
Yatani et al (1986) Bepridil block of cardiac calcium and sodium channels. J.Pharmacol.Exp.Ther. 237 9 PMID: 2420970
Wantanabe and Kimura (2001) Blocking effect of bepridil on Na+/ Ca2+ exchange current in gunea pig cardiac ventricular myocytes. Jpn.J.Pharmacol. 85 370 PMID: 11388640
Sato et al (2006) Bepridil, an antiarrythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection. J.Pharmacol.Exp.Ther. 316 182 PMID: 16174795
Gill et al (1992) Pharmacology of bepridil. Am.J.Cardiol. 69 11D PMID: 1372785
If you know of a relevant reference for Bepridil hydrochloride, please let us know.
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Keywords: Bepridil hydrochloride, Bepridil hydrochloride supplier, calcium, channels, Ca2+, blockers, inhibitors, inhibits, selective, voltage-gated, voltage-dependent, CaV, NCX, sodium-calcium, exchangers, KATP, antiarrhythmics, Non-selective, Cav, Channels, Na+/Ca2+, Exchanger, 4117, Tocris Bioscience
3 Citations for Bepridil hydrochloride
Citations are publications that use Tocris products. Selected citations for Bepridil hydrochloride include:
Yan et al (2019) Blockade of the forward Na+ /Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+ -mediated cell death. Br J Pharmacol 176 2691-2707 PMID: 31034096
Ciapa and Philippe (2013) Intracellular and extracellular pH and Ca are bound to control mitosis in the early sea urchin embryo via ERK and MPF activities. PLoS One 8 e66113 PMID: 23785474
Xiaoli et al (2022) Suppressing Effect of Na+/Ca2+ Exchanger (NCX) Inhibitors on the Growth of Melanoma Cells. Int J Mol Sci 23 PMID: 35055084
Do you know of a great paper that uses Bepridil hydrochloride from Tocris? Please let us know.
Reviews for Bepridil hydrochloride
Average Rating: 5 (Based on 1 Review.)
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Bepridil used on Cav1.2 channels.
By
Anonymous on 02/04/2019
Species: Human
Product used on Cav1.2 channels to understand it blocking mechanism on the specific channel.
