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Discontinued Product
4120 has been discontinued.
View all Glutamate (Metabotropic) Group II Receptors products.
Description: Selectively activates group II mGlu receptors
Chemical Name: 4,8-Dihydroxyquinoline-2-carboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for Xanthurenic acid
Xanthurenic acid is a shown to selectively activate group II mGlu receptors in transfected HEK293 cells at nanomolar concentrations. Attenuates cAMP formation in mouse cortical slices expressing mGlu2 and mGlu3 receptors.
Technical Data for Xanthurenic acid
| M. Wt | 205.17 |
| Formula | C10H7NO4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 59-00-7 |
| PubChem ID | 5699 |
| InChI Key | FBZONXHGGPHHIY-UHFFFAOYSA-N |
| Smiles | OC1=C2C(C(O)=CC(C(O)=O)=N2)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Xanthurenic acid
References for Xanthurenic acid
References are publications that support the biological activity of the product.
Han et al (2007) The tryptophan oxidation pathway in mosquitoes with emphasis on xanthurenic acid biosynthesis. J.Insect.Physiol. 53 254 PMID: 17070835
Mauro et al (2010) Xanthurenic acid, a novel endogenous ligand for metabotropic glutamate receptors. Program No. 643.1/F2. 2010 Neuroscience Meeting Pl 2010 (Online)
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Keywords: Xanthurenic acid, Xanthurenic acid supplier, metabotropic, glutamate, receptors, mGlu, ligands, group, II, 2, mglu2, mglu3, Glutamate, (Metabotropic), Group, Receptors, 4120, Tocris Bioscience
Citations for Xanthurenic acid
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Currently there are no citations for Xanthurenic acid.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.