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Submit ReviewRifampicin
Description: Pregnane X receptor agonist; antibiotic
Alternative Names: Rifampin
Chemical Name: 3-[[(4-Methyl-1-piperazinyl)imino]methyl]-rifamycin
Purity: ≥95% (HPLC)
Biological Activity for Rifampicin
Rifampicin is an antibiotic; inhibits bacterial RNA polymerase. Prototypical activator of the pregnane X receptor (PXR).
Technical Data for Rifampicin
| M. Wt | 822.94 |
| Formula | C43H58N4O12 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 13292-46-1 |
| PubChem ID | 5381226 |
| InChI Key | FZYOVNIOYYPUPY-ZTWDQPHTSA-N |
| Smiles | CN(CC1)CCN1/N=C/C2=C(O)C3=C(C4=O)C5=C(C)C(O)=C3C(O)=C2NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@H]([C@H]([C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O[C@@]4(C)O5)O)C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Rifampicin
References for Rifampicin
References are publications that support the biological activity of the product.
Wehrli (1983) Rifampin: mechanisms of action and resistance. Rev.Infect.Dis. 5 S407 PMID: 6356275
Moore et al (2000) Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J.Biol.Chem. 275 15122 PMID: 10748001
Artsimovitch et al (2005) Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell 122 351 PMID: 16096056
Hu et al (2010) Pregnane X receptor is SUMOylated to repress the inflammatory response. J.Pharmacol.Exp.Ther. 335 342 PMID: 20719936
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⚠ WARNING: This product can expose you to chemicals including Rifampin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
Citations for Rifampicin
Citations are publications that use Tocris products.
Currently there are no citations for Rifampicin.
Reviews for Rifampicin
Average Rating: 5 (Based on 1 Review.)
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Rifampicin resisistance in E.coli cells was studied.
By
Anonymous on 12/03/2018
Assay Type: In Vitro
Species: Human
In our lab rifampicin resisistance in E.coli cells was studied.To assess the level of antibiotic resistance, the minimum inhibitory concentration (MICs) of rifampicin in the non-mutated strain and mutated strain were compared.
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Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.