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Description: SIRT1 and SIRT2 inhibitor
Chemical Name: N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide
Purity: ≥98% (HPLC)
Biological Activity for Salermide
Salermide is a SIRT1 and SIRT2 inhibitor. Exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. Induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis in cancer cells within 24 hours.
Technical Data for Salermide
| M. Wt | 394.47 |
| Formula | C26H22N2O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1105698-15-4 |
| PubChem ID | 53393948 |
| InChI Key | UADRPWLRVLBVBC-UHFFFAOYSA-N |
| Smiles | O=C(C(C)C4=CC=CC=C4)NC1=CC=CC(/N=C/C3=C(O)C=CC2=CC=CC=C23)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Salermide
References for Salermide
References are publications that support the biological activity of the product.
Mai et al (2005) Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors. J.Med.Chem. 48 7789 PMID: 16302818
Lara et al (2009) Salermide, a sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene 28 781 PMID: 19060927
Pasco et al (2010) Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues. J.Med.Chem. 53 1407 PMID: 20041717
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Keywords: Salermide, Salermide supplier, sirt1, sirt2, sirtuin, sir2-like, inhibitors, inhibits, apoptosis, proapoptotic, antitumor, agents, Class, III, HDACs, (Sirtuins), 4127, Tocris Bioscience
Citations for Salermide
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Currently there are no citations for Salermide.
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