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Submit ReviewLY 2087101
Description: Allosteric potentiator of α7, α4β2 and α4β4 nAChRs
Chemical Name: [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone
Purity: ≥98% (HPLC)
Biological Activity for LY 2087101
LY 2087101 is an allosteric potentiator of α7, α4β2 and α4β4 nAChRs; displays selectivity against α3β4 nAChRs. Thought to potentiate agonist-evoked α7 responses by binding within the nAChR transmembrane region.
Compound Libraries for LY 2087101
LY 2087101 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for LY 2087101
| M. Wt | 318.39 |
| Formula | C15H11FN2OS2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 913186-74-0 |
| PubChem ID | 11964458 |
| InChI Key | PEAMDZVDNYENPN-UHFFFAOYSA-N |
| Smiles | O=C(C3=CSC=C3)C1=C(C)N=C(NC2=CC=C(F)C=C2)S1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LY 2087101
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.84 | 100 | |
| ethanol | 3.18 | 10 |
Preparing Stock Solutions for LY 2087101
The following data is based on the product molecular weight 318.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.7 mL | 31.41 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets for LY 2087101
References for LY 2087101
References are publications that support the biological activity of the product.
Broad et al (2006) Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J.Pharmacol.Exp.Ther. 318 1108 PMID: 16738207
Young et al (2008) Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci.U.S.A. 105 14686 PMID: 1879106
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Keywords: LY 2087101, LY 2087101 supplier, allosteric, potentiators, modulators, nicotinic, acetylcholine, receptors, nAChRs, alpha7, α7, a7, LY2087101, Nicotinic, (a7), Receptors, (a4b2), (Other, Subtypes), 4141, Tocris Bioscience
1 Citation for LY 2087101
Citations are publications that use Tocris products. Selected citations for LY 2087101 include:
Haiyang et al (2020) Studying Nicotinic Acetylcholine Receptors Using the IonFlux™ Microfluidic-Based Automated Patch-Clamp System with Continuous Perfusion and Fast Solution Exchange. Curr Protoc Pharmacol 88 e73 PMID: 32068960
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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