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Submit ReviewPIT 1
Description: PIP3 antagonist. Blocks PIP3-PH interaction; inhibits Akt signaling
Chemical Name: N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
Purity: ≥99% (HPLC)
Biological Activity for PIT 1
PIT 1 is a selective PIP3 antagonist. Blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03 μM). Inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Exhibits antitumor activity in vivo.
Technical Data for PIT 1
| M. Wt | 351.76 |
| Formula | C14H10ClN3O4S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 53501-41-0 |
| PubChem ID | 3664359 |
| InChI Key | RIGXBXPAOGDDIG-UHFFFAOYSA-N |
| Smiles | ClC1=C(O)C(NC(NC(C2=CC=CC=C2)=O)=S)=CC([N+]([O-])=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PIT 1
References for PIT 1
References are publications that support the biological activity of the product.
Miao et al (2010) Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc.Natl.Acad.Sci. 107 2012
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Keywords: PIT 1, PIT 1 supplier, PIT1, Supplier, Akt, signaling, inhibitors, inhibits, blocks, PH-PIP3, pleckstrin, homology, PITenins, Inositol, Lipids, Protein, Kinase, B/Akt, 4168, Tocris Bioscience
1 Citation for PIT 1
Citations are publications that use Tocris products. Selected citations for PIT 1 include:
Juvekar et al (2016) Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. Proc Natl Acad Sci U S A 113 E4338 PMID: 27402769
Reviews for PIT 1
Average Rating: 5 (Based on 1 Review.)
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Works well.
By
Anonymous on 05/05/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HCC1937
Induction of PAR and gamma H2ax by the PIP3-mimetic PIT1 (0-100uM)
