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Submit ReviewOzagrel hydrochloride
Description: Selective thromboxane A2 synthetase inhibitor
Alternative Names: OKY 046
Chemical Name: (2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Ozagrel hydrochloride
Ozagrel hydrochloride is a potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM). Does not inhibit prostacyclin (PGI2) synthetase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM). Inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo.
Technical Data for Ozagrel hydrochloride
| M. Wt | 264.71 |
| Formula | C13H12N2O2.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 78712-43-3 |
| PubChem ID | 6438130 |
| InChI Key | CWKFWBJJNNPGAM-IPZCTEOASA-N |
| Smiles | Cl[H].OC(=O)\C=C\C1=CC=C(CN2C=CN=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ozagrel hydrochloride
References for Ozagrel hydrochloride
References are publications that support the biological activity of the product.
Hiraku et al (1986) Pharmacological studies on the TXA2 synthetase inhibitor (E)-3-[p-(1H-imidazol-1ylmethyl)phenyl]-2-propenoic acid (OKY-046). Jpn.J.Pharmacol. 41 393 PMID: 3093741
Naito et al (1983) Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets. Eur.J.Pharmacol. 91 41 PMID: 6413227
Shinagawa et al (2000) Participation of thromboxane A2 in the cough response in guinea-pigs: antitussive effect of ozagrel. Br.J.Pharmacol. 131 266 PMID: 10991919
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Keywords: Ozagrel hydrochloride, Ozagrel hydrochloride supplier, Selective, thromboxane, A2, synthetase, inhibitors, inhibits, Thromboxane, TP, Prostanoid, Synthases, Synthetases, prostaglandins, prostacyclins, eicosanoids, OKY046, 74003-18-2, OKY, 046, Receptors, Other, Synthases/Synthetases, 1510, Tocris Bioscience
2 Citations for Ozagrel hydrochloride
Citations are publications that use Tocris products. Selected citations for Ozagrel hydrochloride include:
Wong et al (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res 104 228 PMID: 19096033
Rancillac et al (2006) Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum. Proc Natl Acad Sci U S A 26 6997 PMID: 16807329
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