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Submit ReviewTorcetrapib
Description: Inhibitor of cholesteryl ester transfer protein (CETP)
Chemical Name: (2R,4S)-4-[[[3,5-bis(Trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline-1-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Biological Activity for Torcetrapib
Torcetrapib is an inhibitor of cholesteryl ester transfer protein (CETP). Also impairs endothelial function in vivo; induces hypertension and inhibits acetylcholine-induced vasodilation in rabbit central ear artery.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for Torcetrapib
| M. Wt | 600.47 |
| Formula | C26H25F9N2O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 262352-17-0 |
| PubChem ID | 159325 |
| InChI Key | CMSGWTNRGKRWGS-NQIIRXRSSA-N |
| Smiles | CC[C@H]2N(C(OCC)=O)C1=CC=C(C(F)(F)F)C=C1[C@@H](N(CC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C(OC)=O)C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Torcetrapib
References for Torcetrapib
References are publications that support the biological activity of the product.
Connelly et al (2010) Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition. J.Cardiovascular Pharmacol. 55 459 PMID: 20051879
Forrest et al (2008) Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increasing circulating levels of aldosterone. Br.J.Pharmacol. 154 1465 PMID: 18536749
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Keywords: Torcetrapib, Torcetrapib supplier, hypercholesterolemia, inhibits, cholesteryl, ester, transferase, protein, CETP, impairs, endothelial, function, Other, Transferases, Lipid, Metabolism, 4184, Tocris Bioscience
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