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Submit ReviewWY 45233 succinate
Description: 5-HT and NA reuptake inhibitor (SNRI)
Alternative Names: Desvenlafaxine
Chemical Name: 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol succinate
Purity: ≥99% (HPLC)
Biological Activity for WY 45233 succinate
WY 45233 succinate is a serotonin and noradrenalin reuptake inhibitor (SNRI); selective for human serotonin (SERT) and noradrenalin (NET) transporters against 96 other targets (Ki values are 40.2 and 558.4 nM for SERT and NET respectively). Inhibits [3H]5-HT and [3H]NE uptake (IC50 values are 47.3 and 531.3 nM). Salt form of the major active metabolite of venlafaxine (Cat. No. 2917).
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for WY 45233 succinate
| M. Wt | 381.46 |
| Formula | C16H25NO2.C4H6O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 448904-47-0 |
| PubChem ID | 9800068 |
| InChI Key | ORUUBRMVQCKYHB-UHFFFAOYSA-N |
| Smiles | OC1(C(CN(C)C)C2=CC=C(O)C=C2)CCCCC1.O=C(CCC(O)=O)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for WY 45233 succinate
References for WY 45233 succinate
References are publications that support the biological activity of the product.
Alfinito et al (2006) Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and NE reuptake inhibitor desvenlaf. succinate in ovariectomized Sprague-Dawley rats. Brain Res. 1098 71 PMID: 16764833
Deecher et al (2006) Desvenlafaxine succinate: a new serotonin and NE reuptake inhibitor. J.Pharmacol.Exp.Ther. 318 657 PMID: 16675639
Mason et al (2007) Desvenlafaxine succinate identifies novel antagonist binding determinants in the human NE transporter. J.Pharmacol.Exp.Ther. 323 720 PMID: 17673606
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.