Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAdenine
Description: Adenine receptor agonist
Chemical Name: 6-Aminopurine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Adenine
Adenine is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). Inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor; also stimulates GTPγS binding (pEC50 values are 8.54 and 7.21 respectively).
Technical Data for Adenine
| M. Wt | 171.59 |
| Formula | C5H5N5.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 2922-28-3 |
| PubChem ID | 76219 |
| InChI Key | UQVDQSWZQXDUJB-UHFFFAOYSA-N |
| Smiles | NC1=C2C(NC=N2)=NC=N1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Adenine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 17.16 | 100 | |
| DMSO | 17.16 | 100 |
Preparing Stock Solutions for Adenine
The following data is based on the product molecular weight 171.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.83 mL | 29.14 mL | 58.28 mL |
| 5 mM | 1.17 mL | 5.83 mL | 11.66 mL |
| 10 mM | 0.58 mL | 2.91 mL | 5.83 mL |
| 50 mM | 0.12 mL | 0.58 mL | 1.17 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Adenine
References for Adenine
References are publications that support the biological activity of the product.
Gorzalka et al (2005) Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues. Mol.Pharmacol. 67 955 PMID: 15604413
Bender et al (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci. 99 8573
If you know of a relevant reference for Adenine, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Adenine, Adenine supplier, p0, receptors, agonists, purinergic, signaling, signalling, Adenine, Receptor, 4202, Tocris Bioscience
Citations for Adenine
Citations are publications that use Tocris products.
Currently there are no citations for Adenine. Do you know of a great paper that uses Adenine from Tocris? Please let us know.
Reviews for Adenine
There are currently no reviews for this product. Be the first to review Adenine and earn rewards!
Have you used Adenine?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.