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Submit ReviewA 887826
Description: Potent voltage-dependent NaV1.8 channel blocker
Chemical Name: 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide
Purity: ≥97% (HPLC)
Biological Activity for A 887826
A 887826 is a potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at NaV1.8 channels compared to NaV1.2 and NaV1.7 channels respectively.
Compound Libraries for A 887826
A 887826 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for A 887826
| M. Wt | 480.99 |
| Formula | C26H29ClN4O3 |
| Storage | Store at RT |
| Purity | ≥97% (HPLC) |
| CAS Number | 1266212-81-0 |
| PubChem ID | 46919335 |
| InChI Key | JPJGFWKHSMUKFO-UHFFFAOYSA-N |
| Smiles | ClC1=C(OCCCC)C=CC(C2=CN=CC(C(NCC3=CC=CN=C3N4CCOCC4)=O)=C2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A 887826
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.05 | 50 |
Preparing Stock Solutions for A 887826
The following data is based on the product molecular weight 480.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.16 mL | 20.79 mL | 41.58 mL |
| 2.5 mM | 0.83 mL | 4.16 mL | 8.32 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.16 mL |
| 25 mM | 0.08 mL | 0.42 mL | 0.83 mL |
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Product Datasheets for A 887826
References for A 887826
References are publications that support the biological activity of the product.
Zhang et al (2010) A-887826 is a structurally novel, potent and voltage-dependent NaV1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats. Neuropharmacology 59 201 PMID: 20566409
If you know of a relevant reference for A 887826, please let us know.
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Keywords: A 887826, A 887826 supplier, A887826, sodium, channel, blocker, blocks, NaV1.8, voltage-dependent, ion, channels, antiallodynic, Voltage-gated, Sodium, Channels, 4249, Tocris Bioscience
1 Citation for A 887826
Citations are publications that use Tocris products. Selected citations for A 887826 include:
Cho et al (2013) Injury-induced HDAC5 nuclear export is essential for axon regeneration. Nat Chem Biol 155 894 PMID: 24209626
Do you know of a great paper that uses A 887826 from Tocris? Please let us know.
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