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Submit ReviewTCN 238
Discontinued Product
4259 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
Description: Positive allosteric modulator of mGlu4 receptors
Chemical Name: (E)-4-(2-Phenylethenyl)-2-pyrimidinamine
Purity: ≥98% (HPLC)
Biological Activity for TCN 238
TCN 238 is a positive allosteric modulator of mGlu4 receptors (EC50 = 1.0 μM for human and rat mGlu4 receptors). Orally available and brain penetrant.
Technical Data for TCN 238
| M. Wt | 197.24 |
| Formula | C12H11N3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 125404-04-8 |
| PubChem ID | 46911068 |
| InChI Key | LNUXNUNUGIHCPA-VOTSOKGWSA-N |
| Smiles | NC1=NC(/C=C/C2=CC=CC=C2)=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TCN 238
References for TCN 238
References are publications that support the biological activity of the product.
East et al (2010) An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg.Med.Chem.Lett. 20 4901 PMID: 20638279
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Keywords: TCN 238, TCN 238 supplier, TCN238, metabotropic, glutamate, mglu4, positive, allosteric, modulators, pams, Glutamate, (Metabotropic), Group, III, Receptors, 4259, Tocris Bioscience
1 Citation for TCN 238
Citations are publications that use Tocris products. Selected citations for TCN 238 include:
Pershina and Arkhipov (2016) Subacute activation of mGlu4 receptors causes the feedback inhibition of its gene expression in rat brain. Life Sci. 153 50 PMID: 27055390
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.