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Submit ReviewTC-H 106
Description: Class I histone deacetylase inhibitor
Chemical Name: N1-(2-Aminophenyl)-N7-(4-methylphenyl)heptanediamide
Purity: ≥99% (HPLC)
Biological Activity for TC-H 106
TC-H 106 is a class I histone deacetylase (HDAC) inhibitor (IC50 values are 150, 370, 760 and 5000 nM for HDAC1, HDAC3, HDAC2 and HDAC8 respectively). Exhibits slow, tight-binding inhibitory activity. Displays no activity against class II HDACs. Brain penetrant.
Technical Data for TC-H 106
| M. Wt | 339.43 |
| Formula | C20H25N3O2 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 937039-45-7 |
| PubChem ID | 16070100 |
| InChI Key | WTKBRPXPNAKVEQ-UHFFFAOYSA-N |
| Smiles | NC1=CC=CC=C1NC(CCCCCC(NC2=CC=C(C)C=C2)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TC-H 106
References for TC-H 106
References are publications that support the biological activity of the product.
Chou et al (2008) Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J.Biol.Chem. 283 35402 PMID: 18953021
Rai et al (2008) HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model. PLoS ONE 3 e1958 PMID: 18463734
Xu et al (2009) Chemical probes identify a role for histone deacetylase 3 in Friedrich's ataxia gene silencing. Chem.Biol. 16 980 PMID: 19778726
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Keywords: TC-H 106, TC-H 106 supplier, TC-H106, histones, deacetylases, hdacs, inhibitiors, class, I, HDAC3, HDAC1, epigenetics, Class, HDACs, 4270, Tocris Bioscience
Citations for TC-H 106
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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