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Rivastigmine tartrate

Cat. No. 4440 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Dual AChE and BChE inhibitor
Alternative Names: ENA 713
Chemical Name: N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester (2R,3R)-2,3-dihydroxybutanedioate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Rivastigmine tartrate

Rivastigmine tartrate is a cholinesterase inhibitor; inhibits both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50 ranges are 4.3-4760 nM and 16-238 nM respectively). Rivastigmine increases α-secretase activity and directs APP processing to the non-amyloidogenic pathway. Brain penetrant.

Compound Libraries for Rivastigmine tartrate

Rivastigmine tartrate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Rivastigmine tartrate

M. Wt 400.42
Formula C14H22N2O2.C4H6O6
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 129101-54-8
PubChem ID 6918078
InChI Key GWHQHAUAXRMMOT-MBANBULQSA-N
Smiles O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN(C)C(=O)OC1=CC=CC(=C1)[C@H](C)N(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rivastigmine tartrate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 40.04 100
DMSO 40.04 100

Preparing Stock Solutions for Rivastigmine tartrate

The following data is based on the product molecular weight 400.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.49 mL 24.97 mL
5 mM 0.5 mL 2.5 mL 4.99 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets for Rivastigmine tartrate

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Rivastigmine tartrate

References are publications that support the biological activity of the product.

Groner et al (2007) The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates. Mol.Pharmacol. 71 1610 PMID: 17347320

Luo et al (2006) Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J.Med.Chem. 49 2174 PMID: 16570913

Mehta et al (2012) New acetylcholinesterase inhibitors for Alzheimer's disease. Int.J.Alzheimers Dis PMID: 22216416

Bailey et al (2011) Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One 6 e21954 PMID: 21799757

Brus et al (2014) J.Med.Chem. 57 8167 PMID: 25226236

If you know of a relevant reference for Rivastigmine tartrate, please let us know.

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1 Citation for Rivastigmine tartrate

Citations are publications that use Tocris products. Selected citations for Rivastigmine tartrate include:

Budzynska et al (2015) Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice. Curr Alzheimer Res 232 931 PMID: 25189792

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Literature in this Area

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