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Description: Inhibitor of γ-glutamyl transpeptidase (GGT)
Chemical Name: 3-[[(3-Amino-3-carboxypropyl)methoxyphosphinyl]oxy]benzeneacetic acid
Purity: ≥95% (HPLC)
Biological Activity for GGsTop
GGsTop is a selective, irreversible γ-glutamyl transpeptidase (GGT) inhibitor; displays no inhibitory effects on glutamine amidotransferases or asparagine synthetase. Suppresses oxidative stress by inhibiting GGT activation. Prevents ischemia/reperfusion-induced acute kidney injury in rats in vivo.
Technical Data for GGsTop
| M. Wt | 331.26 |
| Formula | C13H18NO7P |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 926281-37-0 |
| PubChem ID | 23582776 |
| InChI Key | NTFPDEDRMYYPAC-UHFFFAOYSA-N |
| Smiles | NC(C(O)=O)CCP(OC1=CC=CC(CC(O)=O)=C1)(OC)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GGsTop
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 6.63 | 20 | |
| DMSO | 16.56 | 50 |
Preparing Stock Solutions for GGsTop
The following data is based on the product molecular weight 331.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.04 mL | 30.19 mL | 60.38 mL |
| 2.5 mM | 1.21 mL | 6.04 mL | 12.08 mL |
| 5 mM | 0.6 mL | 3.02 mL | 6.04 mL |
| 25 mM | 0.12 mL | 0.6 mL | 1.21 mL |
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Product Datasheets for GGsTop
References for GGsTop
References are publications that support the biological activity of the product.
Han et al (2007) Design, synthesis, and evaluation of γ-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of γ-glutamyl transpeptidase. Biochemistry 46 1432 PMID: 17260973
Yamamoto et al (2011) Preventive effect of GGsTop, a novel and selective γ-glutamyl transpeptidase inhibitor, on ischemia/reperfusion-induced renal injury in rats. J.Pharmacol.Exp.Ther. 339 945 PMID: 21937737
If you know of a relevant reference for GGsTop, please let us know.
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Keywords: GGsTop, GGsTop supplier, GGsTop, GGT, inhibitors, inhibits, g-GGT, gamma-GGT, γ-GGT, glutamyltransferases, Glutamyl, Transpeptidase, Ischemia, ischaemia, oxidative, stress, Other, Transferases, 4452, Tocris Bioscience
2 Citations for GGsTop
Citations are publications that use Tocris products. Selected citations for GGsTop include:
Elaine Y et al (2018) The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet. Cell 173 1728-1741.e13 PMID: 29804833
Kenji et al (2022) Rapid fluorescent vital imaging of olfactory epithelium. iScience 25 104222 PMID: 35494237
Do you know of a great paper that uses GGsTop from Tocris? Please let us know.
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