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Description: Potent and noncompetitive NMDA antagonist
Alternative Names: CNS 1102
Chemical Name: N-(3-Ethylphenyl)-N-methyl-N'-1-naphthalenylguanidine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Cerestat
Cerestat is a potent and noncompetitive NMDA receptor antagonist (IC50 = 36 nM). Exhibits >70-fold selectivity for NMDA receptor over σ receptor. Neuroprotective in a rat model of focal ischemia.
Technical Data for Cerestat
| M. Wt | 339.86 |
| Formula | C20H21N3.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 137160-11-3 |
| PubChem ID | 60839 |
| InChI Key | CKAKVKWRMCAYJD-UHFFFAOYSA-N |
| Smiles | N=C(N(C)C3=CC=CC(CC)=C3)NC1=C2C(C=CC=C2)=CC=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cerestat
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 16.99 | 50 | |
| DMSO | 33.99 | 100 |
Preparing Stock Solutions for Cerestat
The following data is based on the product molecular weight 339.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.94 mL | 14.71 mL | 29.42 mL |
| 5 mM | 0.59 mL | 2.94 mL | 5.88 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.94 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
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Product Datasheets for Cerestat
References for Cerestat
References are publications that support the biological activity of the product.
Reddy et al (1994) Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist. J.Med.Chem. 37 260 PMID: 8295213
Schäbitz et al (2000) The N-MthD.-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats. Stroke 31 1709 PMID: 10884477
If you know of a relevant reference for Cerestat, please let us know.
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Keywords: Cerestat, Cerestat supplier, CNS1102, potent, noncompetitive, NMDA, receptors, antagonists, selective, neuroprotection, neuroprotective, ischemia, stroke, CNS, 1102, Receptors, 4492, Tocris Bioscience
Citations for Cerestat
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