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Submit ReviewSNS 314 mesylate
Description: Potent pan-Aurora kinase inhibitor
Chemical Name: N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate
Purity: ≥98% (HPLC)
Biological Activity for SNS 314 mesylate
SNS 314 mesylate is a potent, ATP-competitive Aurora kinase inhibitor (IC50 values are 3, 9 and 31 nM for Aurora C, A and B, respectively). Exhibits both in vitro and in vivo activity against human cancer cell lines and tumor xenograft models. Displays additive antiproliferative effects in combination with chemotherapeutics such as carboplatin (Cat. No. 2626), gemcitabine (Cat. No. 3259) and 5-fluorouracil (Cat. No. 3257).
Technical Data for SNS 314 mesylate
| M. Wt | 527.04 |
| Formula | C18H15ClN6OS2.CH3SO3H |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1146618-41-8 |
| PubChem ID | 24995523 |
| InChI Key | FYCODPVDEFFWSR-UHFFFAOYSA-N |
| Smiles | O=C(NC4=CC(Cl)=CC=C4)NC3=NC=C(S3)CCNC1=NC=NC2=C1SC=C2.CS(=O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SNS 314 mesylate
References for SNS 314 mesylate
References are publications that support the biological activity of the product.
Arbitrario et al (2010) SNS-314, a pan-Aurora kinase inhibitor, shows potent and anti-tumor activity and dosing flexibility in vivo. Cancer Chemother. Pharmacol. 65 707 PMID: 19649632
VanderPorten et al (2009) The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model. Mol.Cancer Ther. 8 930 PMID: 19372566
Oslob et al (2008) Discovery of a potent and selective Aurora kinase inhibitor. Bioorg.Med.Chem.Lett. 18 4880 PMID: 18678489
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Cell Cycle and DNA Damage Research Product Guide
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.