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Submit ReviewSEN 1269
Discontinued Product
4699 has been discontinued.
Description: Amyloid-β aggregation inhibitor
Chemical Name: 3-[[5-[3-(Dimethylamino)phenoxy]-2-pyrimidinyl]amino]phenol
Purity: ≥98% (HPLC)
Biological Activity for SEN 1269
Amyloid-β (Aβ) aggregation inhibitor; blocks Aβ(1-42) aggregation and protects neuronal cell lines exposed to Aβ(1-42). Reduces Aβ oligomer-induced LTP and memory deficits in vivo.
Technical Data for SEN 1269
| M. Wt | 322.36 |
| Formula | C18H18N4O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 956128-01-1 |
| PubChem ID | 46835756 |
| InChI Key | MFPAAKZZUIRMKR-UHFFFAOYSA-N |
| Smiles | OC1=CC(NC2=NC=C(OC3=CC=CC(N(C)C)=C3)C=N2)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SEN 1269
References for SEN 1269
References are publications that support the biological activity of the product.
Scopes et al (2012) Aβ oligomer toxicity inhibitor protects memory in models of synaptic toxicity. Br.J.Pharmacol. 167 383 PMID: 22913627
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Keywords: SEN 1269, SEN 1269 supplier, SEN1269, Amyloid-β, (Aβ), aggregation, inhibitors, inhibits, LTP, memory, Alzheimer's, amyloidbeta, amyloidb, Amyloid, Beta, Peptides, 4699, Tocris Bioscience
Citations for SEN 1269
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Currently there are no citations for SEN 1269.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.