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Submit ReviewDecynium 22
Description: PMAT inhibitor
Chemical Name: 1-Ethyl-2-[(1-ethyl-2(1H)-quinolinylidene)methyl]quinolinium iodide
Purity: ≥98% (HPLC)
Biological Activity for Decynium 22
Decynium 22 is an inhibitor of the plasma membrane monoamine transporter (PMAT) (Ki = 0.10 μM).
Technical Data for Decynium 22
| M. Wt | 454.35 |
| Formula | C23H23IN2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 977-96-8 |
| PubChem ID | 101932 |
| InChI Key | GMYRVMSXMHEDTL-UHFFFAOYSA-M |
| Smiles | CC[N+]2=C(/C=C3/N(CC)C(C=CC=C4)=C4C=C3)C=CC1=CC=CC=C12.[I-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Decynium 22
References for Decynium 22
References are publications that support the biological activity of the product.
Engel and Wang (2005) Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Mol.Pharmacol. 68 1397 PMID: 16099839
Xia et al (2009) Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity. Am.J.Physiol.Renal Physiol. 296 F1307 PMID: 19357181
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Keywords: Decynium 22, Decynium 22 supplier, Decynium22, PMAT, plasma, membrane, monoamine, transporters, inhibitors, inhibits, Nucleoside, Transporters, 4722, Tocris Bioscience
1 Citation for Decynium 22
Citations are publications that use Tocris products. Selected citations for Decynium 22 include:
He et al (2017) Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage. Glia 65 1251 PMID: 28543680
Reviews for Decynium 22
Average Rating: 4 (Based on 1 Review.)
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Also a non-competitive alpha-1 adrenoceptor antagonist.
By
Alex Voisey on 10/25/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Aorta
Excellent for blocking organic cation transport at 1 uM in rat aorta. However also acts as non-competitive antagonist of alpha-1 adrenoceptors. This is evidenced by the fact it can block vasoconstrictor responses induced by the alpha-1 adrenoceptor agonist phenylephrine in a non-competitive manner.
