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Description: Inducer of heat shock protein Hsp70
Chemical Name: N-[2-(4-Morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea
Purity: ≥98% (HPLC)
Biological Activity for TRC 051384
TRC 051384 is a inducer of heat shock protein Hsp70; reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke. Activates heat shock factor-1 and results in elevated chaperone and anti-inflammatory activity. Enhances Hsp72 expression in neurons and glial cells.
Technical Data for TRC 051384
| M. Wt | 465.54 |
| Formula | C25H31N5O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 867164-40-7 |
| PubChem ID | 11634093 |
| InChI Key | SQTSPANZQDCPLB-CMDGGOBGSA-N |
| Smiles | O=C(C3=CC=C(NC(NCCN4CCOCC4)=O)C=C3)/C=C/C1=CC=CC(N2CCOCC2)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TRC 051384
References for TRC 051384
References are publications that support the biological activity of the product.
Mohanan et al (2011) Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. Neuropharmacology. 60 991 PMID: 21167846
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Cell Cycle and DNA Damage Research Product Guide
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