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Submit ReviewAL 8697
Description: Potent and selective p38α inhibitor
Chemical Name: N-Cyclopropyl-3-[3-(1,1-dimethylethyl)-6,8-difluoro-1,2,4-triazolo[4,3-a]pyridin-7-yl]-5-fluoro-4-methylbenzamide
Purity: ≥98% (HPLC)
Biological Activity for AL 8697
AL 8697 is a potent and selective p38α inhibitor (IC50 = 6 nM). Exhibits 14-fold greater inhibition of p38α compared to p38β; also displays 300-fold selectivity for p38α compared to a panel of 91 kinases. Exhibits anti-inflammatory properties.
Compound Libraries for AL 8697
AL 8697 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for AL 8697
| M. Wt | 402.41 |
| Formula | C21H21F3N4O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1057394-06-5 |
| PubChem ID | 25060093 |
| InChI Key | ZVBTZTQYHOXIBC-UHFFFAOYSA-N |
| Smiles | CC1=C(F)C=C(C(NC4CC4)=O)C=C1C3=C(F)C2=NN=C(C(C)(C)C)N2C=C3F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AL 8697
References for AL 8697
References are publications that support the biological activity of the product.
Balagué et al (2012) Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. Br.J.Pharmacol. 166 1320 PMID: 22229697
Aiguadé et al (2012) Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. Bioorg.Med.Chem.Lett. 22 3431 PMID: 22521646
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Keywords: AL 8697, AL 8697 supplier, AL8697, potent, selective, p38, alpha, inhibitors, inhibits, anti-inflammatory, 4753, Tocris Bioscience
Citations for AL 8697
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Currently there are no citations for AL 8697.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for AL 8697
