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Submit ReviewBromosporine
Description: Broad spectrum bromodomain inhibitor
Chemical Name: N-[(6-3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate
Purity: ≥98% (HPLC)
Biological Activity for Bromosporine
Bromosporine is a broad spectrum bromodomain inhibitor. Accelerates FRAP recovery of BRD4 and CREBBP in cells at a concentration of 1 μM.
Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the Bromosporine probe summary on the SGC website.
Compound Libraries for Bromosporine
Bromosporine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for Bromosporine
| M. Wt | 404.44 |
| Formula | C17H20N6O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1619994-69-2 |
| PubChem ID | 72943187 |
| InChI Key | UYBRROMMFMPJAN-UHFFFAOYSA-N |
| Smiles | CC1=C(NS(=O)(C)=O)C=C(C3=NN2C(C(NC(OCC)=O)=C3)=NN=C2C)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Bromosporine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.44 | 100 |
Preparing Stock Solutions for Bromosporine
The following data is based on the product molecular weight 404.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.47 mL | 12.36 mL | 24.73 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.95 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.47 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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Product Datasheets for Bromosporine
References for Bromosporine
References are publications that support the biological activity of the product.
Gallenkamp et al (2014) Bromodomains and their pharmacological inhibitors. ChemMedChem 9 438 PMID: 24497428
If you know of a relevant reference for Bromosporine, please let us know.
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Keywords: Bromosporine, Bromosporine supplier, broad, spectrum, bromodomain, inhibitors, inhibits, BRD, sgc, Bromodomains, 4758, Tocris Bioscience
Citations for Bromosporine
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