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Submit ReviewML 239
Description: Breast cancer stem cell inhibitor
Chemical Name: 2-(2,4,6-Trichlorophenoxy)acetic acid (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide
Purity: ≥98% (HPLC)
Biological Activity for ML 239
ML 239 is a breast cancer stem cell inhibitor (IC50 = 1.16 μM). Exhibits 24-fold selectivity for breast cancer stem cells over normal mammary epithelial cells. Also cytotoxic towards MDA-MB-231 breast cancer cells in vitro.
Technical Data for ML 239
| M. Wt | 346.6 |
| Formula | C13H10Cl3N3O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1378872-36-6 |
| PubChem ID | 90488975 |
| InChI Key | WOCCOXNODBCCGK-UHFFFAOYSA-N |
| Smiles | ClC1=C(OCC(N/N=C/C2=CC=CN2)=O)C(Cl)=CC(Cl)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 239
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.66 | 100 | |
| ethanol | 17.33 | 50 |
Preparing Stock Solutions for ML 239
The following data is based on the product molecular weight 346.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.89 mL | 14.43 mL | 28.85 mL |
| 5 mM | 0.58 mL | 2.89 mL | 5.77 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.89 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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Product Datasheets for ML 239
References for ML 239
References are publications that support the biological activity of the product.
Carmody et al (2012) Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells. J.Biol.Chem. 17 1204 PMID: 22941295
Germain et al (2012) Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorg.Med.Chem.Lett. 22 3571 PMID: 22503247
If you know of a relevant reference for ML 239, please let us know.
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Keywords: ML 239, ML 239 supplier, ML239, breast, cancer, stem, cells, inhibitors, inhibits, Cancer, Stem, Cells, 4829, Tocris Bioscience
Citations for ML 239
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Reviews for ML 239
Average Rating: 5 (Based on 1 Review.)
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Action of ML 239 on CSC cell lines.
By
Anonymous on 10/12/2019
Species: Human
ML 239 was tested to find whether it was toxic to two CSC-like lines.Gene expression studies showed altered gene expression in the NF kappa B pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML 239.
Dissolved in DMSO
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