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Submit ReviewLMK 235
Description: Selective HDAC4/HDAC5 inhibitor
Chemical Name: N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethylbenzamide
Purity: ≥98% (HPLC)
Biological Activity for LMK 235
LMK 235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor (IC50 values are 4.22, 11.9, 55.7, 320, 852, 881, and 1278 nM for HDAC 5, 4, 6, 1, 11, 2, and 8, respectively). Demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 = 0.49 and 0.32 μM respectively).
Compound Libraries for LMK 235
LMK 235 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for LMK 235
| M. Wt | 294.35 |
| Formula | C15H22N2O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1418033-25-6 |
| PubChem ID | 71520717 |
| InChI Key | VRYZCEONIWEUAV-UHFFFAOYSA-N |
| Smiles | CC1=CC(C(NOCCCCCC(NO)=O)=O)=CC(C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LMK 235
References for LMK 235
References are publications that support the biological activity of the product.
Marek et al (2013) Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. J.Med.Chem. 56 427 PMID: 23252603
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Keywords: LMK 235, LMK 235 supplier, LMK235, histone, deacetylases, HDAC, inhibitors, inhibits, chemoresistant, cancer, cytotoxicity, Class, II, HDACs, 4830, Tocris Bioscience
4 Citations for LMK 235
Citations are publications that use Tocris products. Selected citations for LMK 235 include:
Chen et al (2015) AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol. Cell Cycle 14 2520 PMID: 26061431
Lu et al (2019) Histone deacetylase 4 promotes type I IF. signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6. Proc Natl Acad Sci U S A PMID: 31127039
Nianli et al (2019) Compounds targeting class II histone deacetylases do not cause panHDACI-associated impairment of megakaryocyte differentiation. Exp Hematol 72 36-46 PMID: 30611870
Alyson E et al (2020) Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth. Cell Chem Biol 27 657-667.e6 PMID: 32220335
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
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