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SR 1078

Cat. No. 4874 Submit a Review Datasheet / COA / SDS
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Description: RORα/γ agonist
Chemical Name: N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SR 1078

SR 1078 is an agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ. Increases transcription of RORα target genes; thought to increase p53 stability.

Licensing Information

Sold under license from The Scripps Research Institute.

Compound Libraries for SR 1078

SR 1078 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 1078

M. Wt 431.25
Formula C17H10F9NO2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1246525-60-9
PubChem ID 17980288
InChI Key DUXWIYXHHGNUJU-UHFFFAOYSA-N
Smiles OC(C(F)(F)F)(C(F)(F)F)C(C=C1)=CC=C1NC(C2=CC=C(C(F)(F)F)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SR 1078

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.12 100
ethanol 43.12 100

Preparing Stock Solutions for SR 1078

The following data is based on the product molecular weight 431.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.59 mL 23.19 mL
5 mM 0.46 mL 2.32 mL 4.64 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for SR 1078

References are publications that support the biological activity of the product.

Wang et al (2010) Identification of a synthetic agonist for the orphan nuclear receptors RORα and RORγ, SR1078. ACS Chem.Biol. 5 1029 PMID: 20735016

Wang et al (2012) Regulation of p53 stability and apoptosis by a ROR agonist. PLoS One 7 e34921 PMID: 22509368

If you know of a relevant reference for SR 1078, please let us know.

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Citations for SR 1078

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