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Description: Calcium-activated chloride channel (CaCC) inhibitor
Chemical Name: 6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
Purity: ≥99% (HPLC)
Biological Activity for CaCCinh-A01
CaCCinh-A01 is a calcium-activated chloride channel (CaCC) inhibitor (IC50 ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50 = 2.1 μM, in TMEM16A-expressing FRT cells).
Technical Data for CaCCinh-A01
| M. Wt | 347.43 |
| Formula | C18H21NO4S |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 407587-33-1 |
| PubChem ID | 2898877 |
| InChI Key | ACLUEOBQFRYTQS-UHFFFAOYSA-N |
| Smiles | CC(C)(C)C1CCC2=C(SC(NC(C3=CC=CO3)=O)=C2C(O)=O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CaCCinh-A01
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.74 | 100 | |
| ethanol | 3.47 | 10 with gentle warming |
Preparing Stock Solutions for CaCCinh-A01
The following data is based on the product molecular weight 347.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.88 mL | 14.39 mL | 28.78 mL |
| 5 mM | 0.58 mL | 2.88 mL | 5.76 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.88 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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Product Datasheets for CaCCinh-A01
References for CaCCinh-A01
References are publications that support the biological activity of the product.
Namkung et al (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J.Biol.Chem. 286 2365 PMID: 21084298
De La Fuente et al (2008) Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol.Pharmacol. 73 758 PMID: 18083779
If you know of a relevant reference for CaCCinh-A01, please let us know.
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Keywords: CaCCinh-A01, CaCCinh-A01 supplier, calcium-activated, chloride, channels, CaCC, inhibitors, inhibits, TMEM16A, Ca2+-Activated, Chloride, Channels, 4877, Tocris Bioscience
7 Citations for CaCCinh-A01
Citations are publications that use Tocris products. Selected citations for CaCCinh-A01 include:
Amjad et al (2015) Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons. J Gen Physiol 145 285 PMID: 25779870
Armen et al (2022) Evidence for tetrodotoxin-resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine. Br J Pharmacol 179 1187-1200 PMID: 34519057
Zaitseva et al (2017) Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine. Cell Host Microbe 22 99 PMID: 28704658
Dwivedi et al (2023) The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells Eur J Pharmacol PMID: 36967079
Rui et al (2020) Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance. Nat Commun 11 2165 PMID: 32358493
Richard C et al (2020) The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. Proc Natl Acad Sci U S A 117 28485-28495 PMID: 33097666
Kamran et al (2023) Cell surface-bound La protein regulates the cell fusion stage of osteoclastogenesis. Nat Commun 14 616 PMID: 36739273
Do you know of a great paper that uses CaCCinh-A01 from Tocris? Please let us know.
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Pathways for CaCCinh-A01
