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Submit ReviewSC 144 hydrochloride
Description: gp130 inhibitor; blocks cytokine-triggered gp130 signaling
Chemical Name: 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl) 2-pyrazinecarboxylic acid hydrazide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for SC 144 hydrochloride
SC 144 hydrochloride is an inhibitor of gp130 (IC50 = 0.72 μM); blocks cytokine-triggered gp130 signaling. SC 144 hydrochloride induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. SC 144 hydrochloride delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active.
Compound Libraries for SC 144 hydrochloride
SC 144 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for SC 144 hydrochloride
| M. Wt | 358.76 |
| Formula | C16H11FN6O.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 917497-70-2 |
| PubChem ID | 66921431 |
| InChI Key | LKFGGXYXFIICED-UHFFFAOYSA-N |
| Smiles | O=C(C4=CN=CC=N4)NNC1=NC(C=C(F)C=C3)=C3N2C1=CC=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SC 144 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.23 | 100 |
Preparing Stock Solutions for SC 144 hydrochloride
The following data is based on the product molecular weight 358.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.79 mL | 13.94 mL | 27.87 mL |
| 5 mM | 0.56 mL | 2.79 mL | 5.57 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.79 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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Product Datasheets for SC 144 hydrochloride
References for SC 144 hydrochloride
References are publications that support the biological activity of the product.
Xu et al (2013) Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. Mol.Cancer Ther. 12 937 PMID: 23536726
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Keywords: SC 144 hydrochloride, SC 144 hydrochloride supplier, SC144, hydrochloride, GP130, inhibitors, inhibits, blocks, cytokine, triggered, gp130, signaling, signalling, Stat3, nuclear, translocation, ovarian, cancer, Cytokines, 4963, Tocris Bioscience
7 Citations for SC 144 hydrochloride
Citations are publications that use Tocris products. Selected citations for SC 144 hydrochloride include:
Anurag et al (2018) Exogenous melatonin protects small-for-size liver grafts by promoting monocyte infiltration and releases interleukin-6. J Pineal Res 65 e12486 PMID: 29505662
Praachi et al (2022) Chronic hM4Di-DREADD-Mediated Chemogenetic Inhibition of Forebrain Excitatory Neurons in Postnatal or Juvenile Life Does Not Alter Adult Mood-Related Behavior. Eneuro 9 PMID: 35115382
Richard et al (2022) Cerebellar modulation of memory encoding in the periaqueductal grey and fear behaviour. Elife 11 PMID: 35287795
Jop et al (2022) A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression. Development 149 PMID: 35993866
Jennifer et al (2019) Sensory perception drives food avoidance through excitatory basal forebrain circuits. Elife 8 PMID: 31074744
Theo et al (2019) Vitronectin from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF. Exp Neurol 312 20-32 PMID: 30408465
Juan et al (2019) Method for Stimulation of Hippocampal Neurogenesis by Transient Microneedle Insertion. Methods Mol Biol 1919 227-235 PMID: 30656634
Do you know of a great paper that uses SC 144 hydrochloride from Tocris? Please let us know.
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Literature in this Area
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