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Submit ReviewCK 869
Description: Arp2/3 inhibitor; inhibits actin polymerization
Alternative Names: CK-0157869
Chemical Name: 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone
Purity: ≥98% (HPLC)
Biological Activity for CK 869
CK 869 is an inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization (IC50= 11 μM). Does not inhibit budding or fission yeast Arp2/3 complexes.
Technical Data for CK 869
| M. Wt | 394.28 |
| Formula | C17H16BrNO3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 388592-44-7 |
| PubChem ID | 3574452 |
| InChI Key | MVWNPZYLNLATCH-UHFFFAOYSA-N |
| Smiles | O=C1N(C3=CC=C(OC)C=C3OC)C(C2=CC=CC(Br)=C2)SC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CK 869
References for CK 869
References are publications that support the biological activity of the product.
Hetrick et al (2013) Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 20 701 PMID: 23623350
Nolen et al (2009) Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 460 1031 PMID: 19648907
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Keywords: CK 869, CK 869 supplier, CK869, CK-0157869, actin-related, protein, Arp2/3, Arp23, complex, actin, polymerization, inhibitors, inhibits, Actin, 4984, Tocris Bioscience
2 Citations for CK 869
Citations are publications that use Tocris products. Selected citations for CK 869 include:
Bharadwaj (2017) αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin. Nat Commun 8 14348 PMID: 28128308
Yamagashi et al (2018) Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo. Biochem.Biophys.Res.Commun. 496 834 PMID: 29395083
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