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SF 1670

Cat. No. 5020 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: PTPN2 and PTEN inhibitor
Alternative Names: PTP Inhibitor XIX
Chemical Name: N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethylpropanamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SF 1670

SF 1670 is a PTPN2 and PTEN inhibitor (IC50values are 0.95 and 1.78 μM, respectively). Increases fMLP-elicited PIP3 signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice. Also inhibits CD45.

Technical Data for SF 1670

M. Wt 307.34
Formula C19H17NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 345630-40-2
PubChem ID 9926586
InChI Key VZQDDSYKVYARDW-UHFFFAOYSA-N
Smiles O=C2C1=CC=CC=C1C3=C(C=C(NC(C(C)(C)C)=O)C=C3)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SF 1670

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.73 100

Preparing Stock Solutions for SF 1670

The following data is based on the product molecular weight 307.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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References for SF 1670

References are publications that support the biological activity of the product.

Li (2011) Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood 117 6702 PMID: 21521784

Le et al (2017) Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: Its role as a multiphosphatase inhibitor. BMB Rep. 50 329 PMID: 28228214

If you know of a relevant reference for SF 1670, please let us know.

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Keywords: SF 1670, SF 1670 supplier, SF1670, PTEN, inhibitors, phosphatase, tensin, homolog, deleted, chromosome, 10, neutrophils, transfusion, inhibits, PTPN2, CD45, cancer, immunotherapy, PTP, Inhibitor, XIX, Protein, Tyrosine, Phosphatases, 5020, Tocris Bioscience

2 Citations for SF 1670

Citations are publications that use Tocris products. Selected citations for SF 1670 include:

Gail A et al (2022) TRAF3 enhances type I interferon receptor signaling in T cells by modulating the phosphatase PTPN22. Sci Signal 15 eabn5507 PMID: 36166512

Lei et al (2017) Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity. J Cell Biol 216 2551 PMID: 28659327

Do you know of a great paper that uses SF 1670 from Tocris? Please let us know.

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