Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTG 4-155
Description: High affinity and selective EP2 receptor antagonist
Chemical Name: (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
Purity: ≥98% (HPLC)
Biological Activity for TG 4-155
TG 4-155 is a high affinity and selective EP2 receptor antagonist (KB values are 2.4 and 34.5 nM for EP2 and DP1 receptors respectively). Exhibits >500-fold selectivity for EP2 over other prostanoid receptors. Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.
Technical Data for TG 4-155
| M. Wt | 394.46 |
| Formula | C23H26N2O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1164462-05-8 |
| PubChem ID | 5886965 |
| InChI Key | YBHUXHFZLMFETJ-MDZDMXLPSA-N |
| Smiles | CC2=CC1=CC=CC=C1N2CCNC(/C=C/C3=CC(OC)=C(OC)C(OC)=C3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TG 4-155
References for TG 4-155
References are publications that support the biological activity of the product.
Jiang and Dingledine (2013) Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation. J.Pharmacol.Exp.Ther. 344 360 PMID: 23192657
Quan et al (2013) EP2 receptor signaling pathways regulate classical activation of microglia. J.Biol.Chem. 288 9293 PMID: 23404506
View Related Products by Target
View Related Products by Product Action
Keywords: TG 4-155, TG 4-155 supplier, TG4-155, high, affinity, selective, EP2, prostanoid, receptors, antagonists, Prostanoid, Receptors, 5052, Tocris Bioscience
2 Citations for TG 4-155
Citations are publications that use Tocris products. Selected citations for TG 4-155 include:
Cuesto et al (2015) GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons. PLoS One 10 e0118475 PMID: 25764078
Donna A et al (2020) Aggregation of Human Mesenchymal Stromal Cells Eliminates Their Ability to Suppress Human T Cells. Front Immunol 11 143 PMID: 32158443
Reviews for TG 4-155
There are currently no reviews for this product. Be the first to review TG 4-155 and earn rewards!
Have you used TG 4-155?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image