Home / Pharmacology / Enzymes / Dehydrogenases / Other Dehydrogenases / Qc 1

Qc 1

Cat. No. 5055 Submit a Review Datasheet / COA / SDS

Discontinued Product

5055 has been discontinued.

View all Other Dehydrogenases products.
Description: Metabolite
Chemical Name: 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Datasheets References

Biological Activity for Qc 1

Qc 1 is a reversible, non-competitive inhibitor of threonine dehydrogenase (TDH) (IC50 ~500 nM). Induces autophagy and inhibits cell proliferation in mouse embryonic stem (ES) cells.

Technical Data for Qc 1

M. Wt 455.45
Formula C23H16F3N3O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 403718-45-6
PubChem ID 5000754
InChI Key IFNVTSPDMUUAFY-UHFFFAOYSA-N
Smiles O=C(N2C3=CC(C(F)(F)F)=CC=C3)C1=CC=C(C(NCC4=CC=CC=C4)=O)C=C1NC2=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Qc 1

References are publications that support the biological activity of the product.

Alexander et al (2011) Targeted killing of a mammalian cell based upon its specialized metabolic state. Proc.Natl.Acad.Sci.USA 108 15828 PMID: 21896756

View Related Products by Target

Keywords: Qc 1, Qc 1 supplier, Qc1, threonine, dehydrogenase, inhibitors, inhibits, TDH, Other, Dehydrogenases, 5055, Tocris Bioscience

Citations for Qc 1

Citations are publications that use Tocris products.

Currently there are no citations for Qc 1.

Reviews for Qc 1

There are currently no reviews for this product. Be the first to review Qc 1 and earn rewards!

Have you used Qc 1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.