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DBM 1285 dihydrochloride

Cat. No. 5095 Submit a Review Datasheet / COA / SDS
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Description: p38 MAPK inhibitor; anti-inflammatory
Chemical Name: N-Cyclopropyl-4-[4-(4-fluorophenyl)-2-(4-piperidinyl)-5-thiazolyl]-2-pyrimidinamine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for DBM 1285 dihydrochloride

DBM 1285 dihydrochloride is a p38 MAPK inhibitor. Supresses p38 phosphorylation and LPS-induced TNF-α production in macrophages and in vivo. Attenuates zymosan-induced inflammation and adjuvant-induced arthritis in murine models. Orally active.

Technical Data for DBM 1285 dihydrochloride

M. Wt 468.42
Formula C21H22FN5S.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1782532-29-9
PubChem ID 90489008
InChI Key ANQWETXPBPZVOF-UHFFFAOYSA-N
Smiles FC(C=C4)=CC=C4C1=C(C2=CC=NC(NC5CC5)=N2)SC(C3CCNCC3)=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DBM 1285 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 46.84 100

Preparing Stock Solutions for DBM 1285 dihydrochloride

The following data is based on the product molecular weight 468.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.67 mL 21.35 mL
5 mM 0.43 mL 2.13 mL 4.27 mL
10 mM 0.21 mL 1.07 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets for DBM 1285 dihydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for DBM 1285 dihydrochloride

References are publications that support the biological activity of the product.

Kang et al (2010) DBM1285 suppresses tumor necrosis factor α production by blocking p38 mitogen-activated protein kinase/mitogen-activated protein kinase-activated protein kinase 2 signaling pathway. J.Pharmacol.Exp.Ther. 334 657 PMID: 20427474

If you know of a relevant reference for DBM 1285 dihydrochloride, please let us know.

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Citations for DBM 1285 dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for DBM 1285 dihydrochloride. Do you know of a great paper that uses DBM 1285 dihydrochloride from Tocris? Please let us know.

Reviews for DBM 1285 dihydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for DBM 1285 dihydrochloride

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.