Home / Pharmacology / Enzyme-Linked Receptors / Toll-like Receptors / Toll-like Receptor Agonists / RWJ 21757

RWJ 21757

Cat. No. 2719 Submit a Review Datasheet / COA / SDS

Discontinued Product

2719 has been discontinued.

View all Toll-like Receptors products.
Description: Toll-like receptor 7 (TLR7) agonist
Alternative Names: Loxoribine,7-Allyl-8-oxoguanosine
Chemical Name: 7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for RWJ 21757

Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.

Technical Data for RWJ 21757

M. Wt 339.3
Formula C13H17N5O6
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 121288-39-9
PubChem ID 60737
InChI Key VDCRFBBZFHHYGT-IOSLPCCCSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N(C(N3CC=C)=O)C2=C3C(NC(N)=N2)=O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for RWJ 21757

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for RWJ 21757

References are publications that support the biological activity of the product.

Goodman et al (1994) Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle. Blood 84 3457 PMID: 7949100

Heil et al (2003) The toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur.J.Immunol. 33 2987 PMID: 14579267

Lee et al (2003) Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of toll-like receptor 7. Proc.Natl.Acad.Sci.USA 100 6646 PMID: 12738885

View Related Products by Target

View Related Products by Product Action

View all Toll-like Receptor Agonists

Keywords: RWJ 21757, RWJ 21757 supplier, Toll-like, receptors, 7, TLR7, agonists, RWJ21757, Loxoribine, 7-Allyl-8-oxoguanosine, Receptors, 2719, Tocris Bioscience

Citations for RWJ 21757

Citations are publications that use Tocris products.

Currently there are no citations for RWJ 21757.

Reviews for RWJ 21757

There are currently no reviews for this product. Be the first to review RWJ 21757 and earn rewards!

Have you used RWJ 21757?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for RWJ 21757

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.