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Submit ReviewPACMA 31
Description: Irreversible protein disulfide isomerase (PDI) inhibitor
Chemical Name: N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycylglycine ethyl ester
Purity: ≥99% (HPLC)
Biological Activity for PACMA 31
PACMA 31 is an irreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.
Compound Libraries for PACMA 31
PACMA 31 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for PACMA 31
| M. Wt | 430.47 |
| Formula | C21H22N2O6S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1401089-31-3 |
| PubChem ID | 66555902 |
| InChI Key | AHOOZADJPNUFOQ-UHFFFAOYSA-N |
| Smiles | O=C(C#C)N(C(C2=CC=CS2)C(NCC(OCC)=O)=O)C1=CC=C(OC)C=C1OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PACMA 31
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.05 | 100 |
Preparing Stock Solutions for PACMA 31
The following data is based on the product molecular weight 430.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.62 mL | 23.23 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.65 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets for PACMA 31
References for PACMA 31
References are publications that support the biological activity of the product.
Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase. ACS.Chem.Biol. 8 2577 PMID: 24070012
Xu et al (2012) Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc.Natl.Acad.Sci.U.S.A. 109 16348 PMID: 22988091
If you know of a relevant reference for PACMA 31, please let us know.
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Keywords: PACMA 31, PACMA 31 supplier, PACMA31, irreversible, protein, disulfide, isomerases, PDI, inhibitors, inhibits, ovarian, cancer, Protein, Disulfide, Isomerase, 5116, Tocris Bioscience
Citations for PACMA 31
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